ADAPT: Active Awards

National Institute of Mental Health, R01MH112545                                                                  


Project Title: 2/3 Community psychosis risk screening: An instrument development study  

Principal Investigators (MPIs): Vijay Mittal, Lauren Ellman, Jason Schiffman                      

Project Period: 7/2017-7/2022                                                                                  

Total Direct Costs: $2,500,000.00                                                                                               

Co-Is: Thomas Olino, Waren Bilker                                                                                                 

Goal: This study, including sites in at Northwestern, Temple, and UMBC, and will recruit twelve thousand adolescents and young adult participants with aims to develop a brief screening instrument (consisting of face valid symptoms as well as less direct, but conceptually relevant,  target variables) designed to identify non-help seeking youth in the community who are likely to benefit from further specialized assessments of psychosis risk (e.g., structured clinical interviews).

National Institute of Mental Health R01  R01MH116039-01A1


Project Title: Developing a Negative Symptom Assessment for Youth at Risk for Psychosis

Principal Investigators (MPI): Greg Strauss, Vijay Mittal

Project Period: 3/01/2019-11/30/2023

Total Direct Costs: $2,458,416

Co-Is: Elaine Walker, Brain Kirkpatrick, Bill Horan, Paul Grant, Rick Zinbarg

Goal: To develop a high sensitive inventory for detecting early negative symptomatology in youth at risk for psychotic disorders

National Institute of Mental Health R01 MH118741


Project Title: An examination of psychomotor disturbance in current and remitted MDD: An RDoC Study

Principal Investigators (MPIs): Stewart Shankman, Vijay Mittal, Sebastian Walther

Total Direct Costs: $2,500,000.00

Project Period: 4/1/2019-3/30/2024

Co-Is: Jessica Bernard, Alex Leow

Consultant: Vinod Menon

Goal: Study motor symptoms in depression from RDoC Framework, and develop a mobile platform for utilizing these markers as an early identification/treatment decision informatics system.

National Institute of Mental Health Translational Research for the Development of Novel Interventions for Mental Disorders: R21/R33 Award, MH103231                                              


Project Title: Exercise and markers of medial temporal health in youth at ultra high-risk for psychosis.                                                                                                                                         

 Principal Investigators (MPIs): Vijay Mittal, Ph.D., Angela Bryan                                                 

Project Period: 07/2014-6/2019                                                                                                       

Total Direct Costs: $850,000                                                                                                            

Co-I: Randal Ross, M.D.                                                                                                                  

Goal: To test feasibility and to design a pilot controlled trial investigation of cardiovascular exercise and medial temporal neurogenesis and cognitive/functioning remediation in youth at high-risk for schizophrenia.

National Institute of Mental Health R21 MH110374                                                              


Project Title: Neural Habituation in Ultra High-Risk Youth                                                      

Principal Investigator: Vijay Mittal, Ph.D.                                                                                  

Project Period: 04/2017-3/2020 (NCE)                                                                                          

Total Direct Costs: $275,000                                                                                                              

Co-Is: Tim Curran, Ph.D., Holly Earls, Ph.D.                                                                                    

Goal: Evaluate timing of affective recognition deficits in youth at clinical high-risk for psychosis.

National Institute of Mental Health R21 MH119677


Project Title: Language features and High-Risk Psychosis Youth

Principal Investigators: Matthew Goldrick, Vijay A Mittal

Project Period: 4/2019-4/30/2021

Total Direct Costs: $275,000

Goal: Project will examine vocal features from the perspective that they may represent a sign of motor dysfunction in youth at high risk for psychosis.  We will use a computational approach to thorough linguistic feature and pattern analysis and follow high-risk youth over time to track course and develop predictive models.

National Institute of Mental Health R21  MH115231                                                             


Project Title: High-Risk Psychosis Youth and Caregivers: Emotion in Interaction                      

Principal Investigators: Claudia Haase, Vijay A. Mittal                                                           

Project Period: 9/2017-8/30/2019                                                                                               

Total Direct Costs: $275,000                                                                                                     

Goal: Project will examine adolescents at high-risk for psychosis and caretakers in a dyadic interaction task to evaluate if patterns of aberrant emotional arousal and regulation predict course of illness.

CHP-R SAMSHA Federal Grant SM-18-012


Title: Community Programs for Outreach and Intervention with Youth and Young Adults at Clinical High Risk for Psychosis

Total Direct Costs: $1,600,000

PIs: State of Illinois, Thresholds

Project Period: 12/2018-11/2022

Consultant: Mittal, Hooker

Goal: To implement a stepped care model to treatment of prodromal syndromes in the Illinois healthcare system.    

National Institute of Mental Health R21, Supplement                                                             


Project Title: High-Risk Psychosis Youth and Caregivers: Emotion in Interaction                 

Principal Investigators: Haase, Mittal                                                                                        

Project Period: 9/2017-8/30/2019                                                                                               

Total Direct Costs: $30,000                                                                                                          

Goal: To evaluate interactive variables from dyads of care-taker/youth in the context of clinical course.

Brain Behavior Research Foundation Independent Investigator Award. (NARSAD)                 


Project Title: Brain stimulation targeting cerebellar-cortical circuits and verbal working memory in psychosis                                                                                                                         

PI: Vijay Mittal, Ph.D.                                                                                                                        

Project Period: 9/15/2017-8/2019                                                                                                       

Total Direct Costs: $99,000                                                                                                           

Co-I: Jessica Bernard                                                                                                                    

Goal: A functional magnetic resonance imaging (fMRI), double-blind cross over study designed to determine if targeted cerebellar brain stimulation will normalize brain activation and behavioral task performance in individuals with schizophrenia performing a verbal working memory task.         


Current Mentored & Sponsored Awards

Brain and Behavior Research Foundation, NARSAD Young Investigator Award               


Project Title: Elucidating the Role of Abnormal Motor Resonance in Social Cognition Deficits in Schizophrenia                                                                                                                            

Principle Investigator: Jerillyn Kent                                                                                           

Project Period: 12/2017-11/19                                                                                                           

Total Direct Costs: $60,000                                                                                                   

Sponsors: Scott Sponheim                                                                                                 

Collaborator: Vijay Mittal                                                                                                                   

Goal: Evaluating the intersection between motor and social functioning deficits in psychosis.       

Brain and Behavior Research Foundation, NARSAD Young Investigator Award                 


Title: Emotion, Mental Health, and Epigenetic clock in high-risk caregivers                        

Principle Investigator: Claudia Haase                                                                                       

Project Period: 12/2017-11/19                                                                                                           

Total Direct Costs: $60,000                                                                                                           

Goal:  To determine how negative emotion during dyadic interaction predicts accelerated epigenetic aging in caregivers of youth at risk for psychosis.                                              

Sponsors: Nina Alexander. Vijay Mittal

Canadian Institutes of Health Research (CIHR), Doctoral Foreign Study Award               


Project Title: Cortical Midline Structures and Self-Reflection in youth at ultra-high risk for psychosis                                                                                                                                       

Principle Investigator:Raffles Cowan                                                                                          

Dates: 9/2017-8/2020                                                                                                                   

Mentors: Dan McAdams, Vijay Mittal

National Academy of Science, Ford Fellowship


Project Title: Early life stress and adult brain structure and cognition

Principle Investigator:Teresa Vargas

Project Period: 6/2019-5/2022

Mentor: Vijay Mittal

Goal: To examine how early experience shape brain development and influence the way people interact with the world they live in.

NIMH National Research Service Award


Project Title: Cumulative environmental risk exposure in youth at clinical high-risk for psychosis

Principle Investigator: Teresa Vargas

Project Period: 2019-2022

Mentor: Mittal, McDade

Goal: To examine if stress during different developmental periods influences adult brain dysfunction and psychosis risk.

NIMH National Research Service Award


Project Title: Neurocorrelates of alterations in facial expressivity in youth at clinical high-risk for psychosis

Principal Investigator: Tina Gupta 2019-2021

Mentor: Mittal, Haase

Goal: To examine underlying neural circuitry in motor and limbic networks of alterations in facial expressivity in psychosis risk. 


Past Awards

National Institute of Health, R01MH094650                                                                             


Project Title: Frontal-Subcortical Development, Movement Abnormalities, and Risk for Psychosis                                                                                                                                   

Principal Investigator: Vijay A. Mittal, Ph.D.                                                                                       

Project Period: 06/01/2011-02/29/2018                                                                                        

Total Direct Cost: $1,820,544                                                                                                           

Co-Is: Randal Ross, M.D., Marie Banich Ph.D., Mark Brown Ph.D.                                                    

Goal: Investigate spontaneous movement abnormalities as a potential biomarker for white matter and grey matter development components of frontal-subcortical circuits, in adolescents at high-risk for psychosis.

Buffett Institute for Global Study, Scholars in Israel Collaboration                                             


P.Is Matthew Goldrick, Vijay Mittal, Emily Cibelli, Joseph Keshet, Yossi Adi, Jennifer Cole        

Date: 06/2017-5/2017                                                                                                                      

Total Award: $25,000                                                                                                                        

Title: A Multidisciplinary Approach to Predicting Schizophrenia                                                           

Goal: To use machine learning to evaluate movement markers of risk for psychosis.

Northwestern Weinberg College Research and Innovation Grant (W Award)                          


Project Title: Using motor control disruptions in speech to predict risk for psychotic disorders

Principle Investigator: Emily Cibelli, Matthew Goldrick (Department of Linguistics); Vijay Mittal  

Direct Costs: $35,000                                                                                                                 

Project Period: 9/2017-8/2018                                                                                                          

Goal: To develop software for analyzing speech patterns indicating increased risk for psychosis.    

Northwestern Data Science Initiative Award                                                                                  


Project Title: Automated analysis of vocal characteristics for early detection of schizophrenia  

Project Period: 06/2016-05/2017                                                                                               

Principle Investigator: Emily Cibelli, Ph.D.  Matthew Goldrick, Ph.D. Vijay Mittal, Ph.D.               

Total Direct Costs: $30,000                                                                                                             

Goal: To Evaluate early motor dysfunction in speech signifying risk for psychosis.

Intermountain Neuroimaging Consortium (INC) Pilot Award                                                


Project Title: Default Mode Network Hyperconnectivity Across theSchizophrenia Spectrum    

PI: Vijay Mittal and Jessica Turner                                                                                               

Project Period: 2012-2013                                                                                                              

Goal: To examine potential hyperconnectivity patterns across the psychosis spectrum

National Institute of Health (NIH) Clinical Research Loan Repayment Award (2009-2012) NIH- L30 MH087258:01-02                                                                                                         


Project Title: Dyskinetic Movements and Glucocorticoids in Adolescents At-Risk for Psychosis

Principal Investigator: Vijay A. Mittal, Ph.D.                                                                                 

Goal: This project is designed to investigate the roles between stress reactivity, reciprocal dopamine activation, and potentially consequent neuromotor dysfunction

National Institute of Mental Health (NIMH) National Research Service Award (NRSA)/Training NIMH NRSA T32 MH14584-33                                                                    


Principal Investigator: Keith Nuechterlein, Ph.D., University of California Los Angeles, Department of Psychology                                            

Role: Postdoctoral Fellow


Past Mentored Awards

Brain Behavior Research Foundation: NARSAD Young Investigator Award                               


Project Title: Cerebello Prefrontal Involvement in Error Processing and Rule Learning in Youth at Ultra High-Risk for Psychosis                                                                                                          

Principle Investigator Jessica Bernard, Ph.D.                                                                                  

Project Period: 1/1/2015-1/1/2017                                                                                                         

Total Direct Costs: $60,000                                                                                                                

Mentor: Vijay Mittal, Ph.D. Co Mentor: Banich

National Research Service Award (NRSA), 1F31MH100821-01A1                                                  


Project Title: The neural basis of social cognition in adolescence                                               

Project Period: 10/01/2013-9/30/2016                                                                                                

Principle Investigator Andrea Pelletier, M.A.                                                                           

Mentor: Vijay Mittal, Ph.D. Co-Mentors: Tor Wager, Jessica Turner

National Research Service Award (NRSA) 1F32MH102898-01                                                    


Project Title: Cerebellar contributions to disease course in youth at high-risk of psychosis       

Project Period: 10/01/2013-9/30/2015                                                                                                 

Principle Investigator: Jessica Bernard, Ph.D.                                                                                  

Mentor: Vijay Mittal, Ph.D. Co-Mentor: Marie Banich, Jessica Turner